Hypo- and hyperresponders to dietary cholesterol

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Pre-menopausal women, classified as hypo- or hyperresponders, do not alter their LDL/HDL ratio following a high dietary cholesterol challenge.

BACKGROUND Cholesterol is the dietary component that has elicited the most public interest in conjunction with coronary heart disease. However, the impact of excess dietary cholesterol intake on plasma cholesterol levels cannot be accurately predicted; therefore, its role in disease progression is not straightforward. Individual response variation can be due to factors such as ethnicity, hormon...

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CETP activity in liver perfusates and plasma from rabbits hypo- or hyperresponsive to dietary cholesterol.

We investigated the relationship between the development of hypercholesterolemia in rabbits and cholesteryl ester transfer protein (CETP) activity secretion by their perfused livers. Two inbred strains of rabbits were compared which differ markedly in their hypercholesterolemic response to dietary cholesterol. Feeding a high-cholesterol (0.3%) diet, increased plasma and liver cholesterol level ...

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Hyper- and hypo-responsiveness to dietary fat and cholesterol among inbred mice: searching for level and variability genes.

A concept proposed by Berg (Berg, K. 1989. Arteriosclerosis. 9: I-50-I-58) is that a combination of level and variability genes determine an individual's overall plasma lipid levels and atherosclerotic risk. Our goal was to determine which inbred mouse strains could be used to identify candidate level and variability genes controlling lipid levels and atherosclerosis susceptibility. Nine common...

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Relationship between sensitivity to dietary fat and dietary cholesterol.

A group of 56 hypercholesterolemic and normocholesterolemic men and women were given approximately 700 mg a day of egg yolk cholesterol in a double-blind, crossover study while they were on a background diet containing approximately 30% of energy as fat. Overall there was a 0.23 mmol/l rise in plasma cholesterol (3.7%, p less than 0.001) after 4 weeks, a 0.19 mmol/l rise in low density lipoprot...

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Rate of Cholesterol Synthesis in Hypo- and Hyperthyroid Rats

The rate of cholesterol synthesis, measured by the rate of incorporation of tritium from body water into the cholesterol molecule, was found to be greater than normal in the hyperthyroid rat and below normal in the hypo-thyroid rat.

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ژورنال

عنوان ژورنال: The American Journal of Clinical Nutrition

سال: 1986

ISSN: 0002-9165,1938-3207

DOI: 10.1093/ajcn/43.6.974b